CURCUMIN

One of the most investigated plants in biomedical research

About CURCUMIN

Also known as turmeric, the root of the plant is a common spice in Indian and other Asian cuisines. It was introduced to the Western world in the 14th century

USE SINCE ANCIENT TIMES

For 5000 years, the paste and extracts of the root have been used in Asia to treat a variety of ailments, from infections to inflammation, arthritis and cancer. The use continues to this day: dissolved in warm milk to fight off cough and cold, and digestive disorders; a paste applied to ward off pain, to heal wound and burns, and to treat skin diseases.

OSTEOARTHRITIS & CURRENT MEDICATIONS

The condition occurs when the protective cartilage on the end of the bones wears down, causing joint pain and stiffness in the hands, knees, hips and spine. It is treated with different classes of pain killers, and steroids. Each one produces unwelcome side effects on the liver and kidney, GI and cardiovascular systems.

MAKING CURCUMIN CLINICALLY EFFECTIVE

Unfortunately, curcumin in its naturally existing form is unstable and poorly soluble and isn’t well absorbed by the body, limiting its clinical benefits.

CURRENT CLINICAL INVESTIGATIONS

Curcumin is the subject of more than 3,000 pre-clinical investigations—more than 60 clinical trials are registered with the U.S. National Institutes of Health (NIH)—in conditions ranging from inflammation to arthritis, cancer, and diabetes.

CURCUMIN IN MANAGEMENT OF OSTEOARTHRITIS

Recent studies have produced a vast body of evidence of its beneficial effects in managing inflammation and osteoarthritis.

IMPROVING BIOAVAILABILITY

A number of formulations with delivery technology have been reported in recent years as offering a form of curcumin that is stable and highly absorbed by the body. One such delivery technology is the patented “phytosome” form MERIVA® [1] in which curcumin is safely tucked inside a commonly used fatty compound of soybean, lecithin, (a good dispersing agent used in pharmaceuticals) and delivered to the body’s cell membrane. This results is a 20-fold absorption over the normal curcumin.

SAFETY OF CURCUMIN

Curcumin has no serious demonstrated side effects, and the increase in bioavailability does not translate into increased toxicity.

In a small study curcumin has shown to be effective in curbing heart burn and upset stomach

A 2012 study shows curcumin may be effective in delaying onset of Type 2 diabetes

In cancer treatment studies are in early stages, but animal studies show curcumin’s benefits in fighting off cancer

According to the American Cancer Society, curcumin “interferes with several important molecular pathways involved in cancer development, growth and spread”

Mayo Clinic reports that laboratory and animal research suggests that curcumin may slow the spread of cancer

Each batch is tested and certified to ensure it is free of microbial and other contaminants

Curcumin has shown to preserve muscular mass in healthly aging patients

A HIGHLY ABSORBABLE MERIVA®

MERIVA® is a curcumin complex, its safety and efficacy supported by clinical trials. The studies show that

It is 20-fold more bioavailable versus the standard 95% turmeric extracts

It is safe and effective as adjunct in mild to moderate Osteoarthritis

It reduced the score measuring pain, stiffness and impaired physical function by 58%

It decreased the patient’s use of pain killers by 63%, along with an associated significant reduction in gastrointestinal adverse effects and costs

It has been granted “Generally Recognized as Safe (GRAS)” by the US FDA

ABOUT PARADIGM PHARMA

Paradigm Pharmaceuticals Inc., a New York, U.S., company offers dietary supplements along with pharmaceuticals. It markets supplements whose benefits are sufficiently supported by scientific and clinical evidence to offer as natural and complementary medicines.

It manufactures at GMP-certified plants, with each production batch tested and certified for the claimed composition and safety

BioCurcuma

Curcumin's beneficial compounds in patented technology - Curcumin (commonly known as Turmeric)

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